A Convenient Propargylating Agent. 3-Bromo-1-Trimethylisilyl-1-Propyne
- 1 January 1972
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 2 (5), 267-272
- https://doi.org/10.1080/00397917208061979
Abstract
In the course of a synthetic approach to the Gibberellic acid skeleton,1 we desired to introduce a propargyl group by alkylation of a properly substituted cyclohexanone. Direct alkylation with propargyl bromide proved to be unsuccessful in terms of synthetic utility. Therefore a study was undertaken to investigate the introduction of a propargyl group by alkylation of a ketone. The result of this study is the subject of this communication.Keywords
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- 520. The chemistry of the triterpenes and related compounds. Part XVIII. Elucidation of the structure of polyporenic acid CJournal of the Chemical Society, 1953
- 720. Researches on acetylenic compounds. Part XXVI. Further Reformatsky reactions with propargyl bromidesJournal of the Chemical Society, 1950