The Delayed Effects of Ethacrynic Acid on the Stria Vascularis of the Guinea Pig

Abstract

Guinea pigs were administered 40 mg ethacry-nic acid per kg b.wt. and sacrificed at 30–48 minutes, 34- hours, 2 or 7 days post-drug. Cochlear potentials (EP and CP) were monitored before sacrifice. At 30–48 minutes, the potentials had decreased considerably, and a marked edema plus cytological changes were visible in the stria vascularis. The potentials had recovered to about 75 % of their original value at 3–4 hours; some cell recovery was visible, but the edema was still present. Potentials recorded from the basal turn were normal at 2 and 7 days, although some strial cells showed deterioration.