Mosaic Histocompatibility of Skin Grafts from Female Mice

Abstract

The histoincompatibility determined by one or more genes on the X chromosome of the mouse effects a complete rejection of skin of the (C57BL/6 ♀ x BALB/c ♂) F₁ hybrid male grafted onto the reciprocal type F₁ hybrid male, but only an incomplete rejection of either reciprocal type F₁ hybrid female skin, grafted onto the same type of male host. The resulting mosaic survival pattern of the female graft is interpreted as support for the Lyon hypothesis of X-chromosome inactivation.