A CHANGE IN OPTICAL ROTATION OF CREATINE-ATP TRANSPHOSPHORYLASE DURING ENZYME SUBSTRATE INTERACTION SUGGESTING AN ALTERATION IN CONFORMATION
- 1 December 1961
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 47 (12), 1992-1996
- https://doi.org/10.1073/pnas.47.12.1992
Abstract
The specific rotation and rotatory dispersion of creatine-ATP-transphosphorylase has been measured and found to follow the single term Drude equation between 313 and 589m [mu]. The enzyme has been found to undergo a small but consistent increase in specific rotation only when in equilibrium with all of its substrates, which suggests a conformation change during activity.Keywords
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