THE TOXIC FACTORS IN EXPERIMENTAL TRAUMATIC SHOCK. IV. THE EFFECTS OF THE INTRAVENOUS INJECTION OF THE EFFUSION FROM ISCHEMIC MUSCLE 1

Abstract

The exudate which accumulates after muscle anoxia was collected and injected into recipient dogs. In three-quarters of such observations no evidence of shock developed, while in one-quarter of the animals shock was produced by this technique and caused death. The inconstancy of the presence of this toxic factor suggests it is an extraneous agent, not present in the usual cellular constituents and metabolic products found in all muscle exudates. Since the exudates are invariably contaminated with bacteria, it is thought that the toxin may be bacterial in origin.