Cholinergic Receptor Site Binding, Choline Acetyltransferase, and Acetylcholinesterase Activity in the Forebrain and Brainstem of the Dahl Rat Model of Essential Hypertension
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 5 (10), 1683-1702
- https://doi.org/10.3109/10641968309051802
Abstract
Muscarinic and nicotinic receptor site binding and the activity of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the forebrain and brainstem of Dahl salt-sensitive (DS) and salt-resistant (DR) rats was investigated. The DS line had a greater density of muscarinic sites in the cortex, hypothalamus, and medulla. Hypertensive DS rats had a greater density of sites than normotensive DS rats. ChAT activity was also higher in the cortex and hypothalamus of the DS line than the DR line. No significant differences were found in the activity of AChE or the concentration of nicotinic sites. These results suggest that the central muscarinic cholinergic system may participate in the pathogenesis of hypertension in the DS rat. The data indicate that central cholinergic activity is possibly greater in the DS than the DR rat and that this may help to explain the enhanced pressor response in the DS line after pharmacological activation of the central cholinergic system.Keywords
This publication has 15 references indexed in Scilit:
- Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous SystemAnnual Review of Pharmacology and Toxicology, 1982
- Role of Central Cholinergic Neurons in Experimental HypertensionJournal of Cardiovascular Pharmacology, 1980
- Activity of choline acetyltransferase and acetylcholinesterase in the goldfish optic tectum after disconnectionNeurochemical Research, 1979
- Pharmacological study of a cholinergic mechanism within the rat posterior hypothalamic nucleus which mediates a hypertensive responseBrain Research, 1979
- Differential Development of Salt-Induced and Renal Hypertension in Dahl Hypertension-Sensitive Rats After Neonatal SympathectomyClinical and Experimental Hypertension, 1979
- The Effect of Chronic Conflict on the Blood Pressure of Rats with a Genetic Susceptibility to Experimental HypertensionPsychosomatic Medicine, 1975
- Primary role of renal homografts in setting chronic blood pressure levels in rats.Circulation Research, 1975
- A rapid radiochemical method for the determination of choline acetyltransferaseJournal of Neurochemistry, 1975
- A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology, 1961
- Microphonic Manometer for Indirect Determination of Systolic Blood Pressure in the Rat.Experimental Biology and Medicine, 1949