Desferrioxamine as a lipid chain‐breaking antioxidant in sickle erythrocyte membranes
- 7 May 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 264 (1), 145-148
- https://doi.org/10.1016/0014-5793(90)80786-i
Abstract
The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron-induced oxidative damage has been ascribed to its ability to chelate available ferric ion (K b = 1031). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the Superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non-haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.Keywords
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