Bioadhesive Tablets Influence of the Testing Medium Composition on Bioadhesion
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 15 (12), 2037-2048
- https://doi.org/10.3109/03639048909052517
Abstract
A bioadhesive tablet of metronidazole has been developed for oral or vaginal administration. The bioadhesive component is poly(acrylic acid) (Carbopol 934), and the matrix component is hydroxypropyl methylcellulose (HPMC K4M). The influence of the test medium was investigated in order to determine the adhesion of the tablet during routine use by the various routes. The parameter retained to evaluate adhesion was the adhesion work on a biological tissue. The factors whose influence was investigated were pH, ionic force and nature of cations, and type of biological substrateThis publication has 15 references indexed in Scilit:
- Final Report on the Safety Assessment of Carbomers-934, -910, -934P, -940, -941, and -962Journal of the American College of Toxicology, 1990
- Preliminary studies of oral mucosal delivery of peptide drugsJournal of Controlled Release, 1987
- Bioadhesive microspheres as a potential nasal drug delivery systemInternational Journal of Pharmaceutics, 1987
- Bioadhesive analysis of controlled-release systems. II. Time-Dependent bioadhesive stress in poly(acrylic acid)-containing systemsJournal of Controlled Release, 1987
- Bioadhesive analysis of controlled-release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systemsJournal of Controlled Release, 1987
- Bioadhesive analysis of controlled-release systems. III. Bioadhesive and release behavior of metronidazole-containing poly(acrylic acid)-hydroxypropyl methylcellulose systemsInternational Journal of Pharmaceutics, 1987
- Titration of poly(acrylic acid) and poly(methacrylic acid) in methanolMacromolecules, 1987
- Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesionJournal of Controlled Release, 1985
- Solvent effects in polyelectrolyte systems. 3. Spectrophotometric results with (partially) neutralized poly(acrylic acid) in methanol and general conclusions regarding these systemsMacromolecules, 1984
- Solvent effects in polyelectrolyte solutions. 1. Potentiometric and viscosimetric titration of poly(acrylic acid) in methanol and counterion specificityMacromolecules, 1984