Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
Top Cited Papers
Open Access
- 2 January 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 131 (3), 890-891
- https://doi.org/10.1021/ja807334b
Abstract
We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.Keywords
This publication has 23 references indexed in Scilit:
- A cell nanoinjector based on carbon nanotubesProceedings of the National Academy of Sciences, 2007
- Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell typeNature Nanotechnology, 2007
- Cellular Toxicity of Carbon-Based NanomaterialsNano Letters, 2006
- Interfacing Carbon Nanotubes with Living CellsJournal of the American Chemical Society, 2006
- Label-free detection of DNA hybridization using carbon nanotube network field-effect transistorsProceedings of the National Academy of Sciences, 2006
- Multi-walled carbon nanotubes induce T lymphocyte apoptosisToxicology Letters, 2006
- Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destructionProceedings of the National Academy of Sciences, 2005
- Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivoMolecular BioSystems, 2005
- Effect of single wall carbon nanotubes on human HEK293 cellsToxicology Letters, 2004
- Covalently functionalized nanotubes as nanometre- sized probes in chemistry and biologyNature, 1998