Binding of antimalarial drugs to hemozoin fromPlasmodium berghei
- 1 September 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (9), 1063-1064
- https://doi.org/10.1007/bf01965970
Abstract
Chloroquine, quinacrine and mefloquine bind toPlasmodium berghei hemozoin, hemin, heme, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.This publication has 15 references indexed in Scilit:
- Plasmodium lophurae: Composition and properties of hemozoin, the malarial pigmentExperimental Parasitology, 1979
- Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to MefloquineAntimicrobial Agents and Chemotherapy, 1979
- Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutaseCell Biology International Reports, 1978
- MalariaNew England Journal of Medicine, 1977
- Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNANature, 1975
- Location of chloroquine binding sites in plasmodium bergheiBiochemical Pharmacology, 1971
- Studies concerning the mechanism of action of antimalarial drugs—II: Inhibition of the incorporation of adenosine-5'-monophosphate-3H into nucleic acids of erythrocyte-free malarial parasitesBiochemical Pharmacology, 1971
- CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDINGProceedings of the National Academy of Sciences, 1969
- HEMOGLOBIN SYNTHESIS IN RABBIT RETICULOCYTES IN VITROJournal of Biological Chemistry, 1956
- Complex Ions. III. A Study of Some Complex Ions in Solution by Means of the Spectrophotometer1Journal of the American Chemical Society, 1942