Linking the epigenetic ‘language’ of covalent histone modifications to cancer
Open Access
- 17 February 2004
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 90 (4), 761-769
- https://doi.org/10.1038/sj.bjc.6601575
Abstract
Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.Keywords
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