Presence of the KPC Carbapenemase Gene in Enterobacteriaceae Causing Bacteremia and Its Correlation with In Vitro Carbapenem Susceptibility
- 1 January 2009
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 47 (1), 239-241
- https://doi.org/10.1128/jcm.02123-08
Abstract
During 6 months, we obtained Enterobacteriaceae isolates from patients with gram-negative bacteremia at a 1,250-bed teaching hospital in St. Louis, MO, and compared carbapenem susceptibilities with the presence of bla KPC , a transferable carbapenemase gene. Three (1.2%) out of 243 isolates were bla KPC positive. Ertapenem nonsusceptibility had a low positive predictive value.Keywords
This publication has 20 references indexed in Scilit:
- Detection of KPC-2 in a Clinical Isolate of Proteus mirabilis and First Reported Description of Carbapenemase Resistance Caused by a KPC β-Lactamase in P. mirabilisJournal of Clinical Microbiology, 2008
- Screening for antibiotic resistant Gram-negative bacteriaThe Lancet Infectious Diseases, 2006
- Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for DetectionAntimicrobial Agents and Chemotherapy, 2005
- Rapid Spread of Carbapenem-Resistant Klebsiella pneumoniae in New York CityArchives of Internal Medicine, 2005
- Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agentsJournal of Antimicrobial Chemotherapy, 2005
- Bloodstream Infections Caused by Antibiotic-Resistant Gram-Negative Bacilli: Risk Factors for Mortality and Impact of Inappropriate Initial Antimicrobial Therapy on OutcomeAntimicrobial Agents and Chemotherapy, 2005
- Outbreak of Klebsiella pneumoniae Producing a New Carbapenem-Hydrolyzing Class A β-Lactamase, KPC-3, in a New York Medical CenterAntimicrobial Agents and Chemotherapy, 2004
- Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolatesJournal of Antimicrobial Chemotherapy, 2003
- Occurrence of Newer β-Lactamases in Klebsiella pneumoniae Isolates from 24 U.S. HospitalsAntimicrobial Agents and Chemotherapy, 2002
- Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain ofKlebsiella pneumoniaeAntimicrobial Agents and Chemotherapy, 2001