Bovine Protoporphyria: The First Nonhuman Model of This Hereditary Photosensitizing Disease
- 14 October 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4313), 199-201
- https://doi.org/10.1126/science.905823
Abstract
Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.This publication has 12 references indexed in Scilit:
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