Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes
- 1 January 1992
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 6 (2), 147-152
- https://doi.org/10.1111/j.1365-2958.1992.tb01995.x
Abstract
This review explores the underlying biochemical and genetic principles leading to the formation of hybrid anthraquinones by recombinant anthracycline-producing streptomycetes transformed with genes encoding the early steps in actinorhodin biosynthesis. Experiments indicate that simple aromatic polyketides are probably synthesized using very similar mechanisms, allowing for the interspecies cloning of polyketide synthase genes for the potential production of novel aromatic polyketide structures.Keywords
This publication has 24 references indexed in Scilit:
- Drug Development through the Genetic Engineering of Antibiotic-Producing MicroorganismsAnnals of the New York Academy of Sciences, 1991
- Polyketide synthase com plexes: their structure and function in antibiotic biosynthesisPhilosophical Transactions Of The Royal Society B-Biological Sciences, 1991
- Modular Organization of Genes Required for Complex Polyketide BiosynthesisScience, 1991
- Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibioticsMolecular Microbiology, 1990
- Biosynthesis of anthracydines: enzymic conversion of aklanonic acid to aklavinone and -rhodomycinone by anthracycline-producing streptomycetesJournal of General Microbiology, 1990
- Biosynthesis of anthracyclines: analysis of mutants of Streptomyces sp. strain C5 blocked in daunomycin biosynthesisJournal of General Microbiology, 1990
- Mutactin, a novel polyketide from Streptomyces coelicolor. Structure and biosynthetic relationship to actinorhodinThe Journal of Organic Chemistry, 1990
- Molecular Genetics of Polyketides and its Comparison to Fatty Acid BiosynthesisAnnual Review of Genetics, 1990
- Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolorGene, 1988
- Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)Journal of General Microbiology, 1979