EXCRETION OF ANTIBIOTICS IN BILE

Abstract

The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6-aminopenicillanic acid, are rapidly excreted, reabsorbed and re-excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p-Aminobenzylpenicillin and d(—)-6-(α-amino-α-phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other conforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance.