IDENTIFICATION OF DERMORPHIN AND HYP6‐DERMORPHIN IN SKIN EXTRACTS OF THE BRAZILIAN FROG PHYLLOMEDUSA RHODEI
- 1 March 1981
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 17 (3), 316-321
- https://doi.org/10.1111/j.1399-3011.1981.tb01997.x
Abstract
Methanol extracts of the skin of the Brazilian frog P. rhodei contain approximately equal amounts of dermorphin and its analog Hyp6-dermorphin, 2 opiate-like heptapeptides. A unique feature of their sequence is the presence of a D-amino acid residue at position 2. Hyp6-dermorphin possesses a spectrum of central and peripheral bioactivity very similar to that of dermorphin.Keywords
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