Stereospecific blockade of N-methyl-d-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning
- 31 May 1990
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 101 (2), 287-288
- https://doi.org/10.1007/bf02244143
Abstract
In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-d-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (−) MK 801 was without effect. The results indicate that the N-methyl-d-aspartate receptor exerts a permissive role on priming.Keywords
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