Response of murine spermatocytes to the metaphase-arresting effect of several mitotic arrestants
- 1 December 1985
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 41 (12), 1586-1588
- https://doi.org/10.1007/bf01964819
Abstract
Three mitotic arrestants, colchicine, Colcemid and vinblastine, were evaluated for their effects on producing meiotic arrest in the laboratory mouse. Colchicine is the most effective and its effect is both dose- and time-dependent. Treatment of mice with 40 mg/kg of colchicine for 3 h resulted in drastic improvement of the yield and quality of M-II figures. This treatment did not appear to increase the aneuploidy frequency in M-II's.This publication has 7 references indexed in Scilit:
- Induction of aneuploidy by mitotic arrestants in mouse bone marrowMutation Research/Genetic Toxicology, 1985
- Nondisjunction induced in mouse spermatogenesis by chloral hydrate, a metabolite of trichloroethyleneEnvironmental Mutagenesis, 1984
- Perspectives in mutation epidemiology: 3. Contribution of chromosome abnormalities to human morbidity and mortality and some comments upon surveillance of chromosome mutation ratesMutation Research/Reviews in Genetic Toxicology, 1983
- Cytogenetic observations, in mouse secondary spermatocytes, on numerical and structural chromosome aberrations induced by cyclophosphamide in various stages of spermatogenesisMutation Research Letters, 1983
- Systematic approach to the study of trisomy in the mouse. IICytogenetic and Genome Research, 1975
- A quantitative study of the second meiotic metaphase in male mice (Mus musculus)Cytogenetic and Genome Research, 1975
- An Air-Drying Method for Meiotic Preparations from Mammalian TestesCytogenetic and Genome Research, 1964