Curing of an Escherichia coli Episome by Rifampicin
- 1 February 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (2), 298-300
- https://doi.org/10.1073/pnas.69.2.298
Abstract
Low doses of rifampicin, an antibiotic that specifically inhibits RNA polymerase, cure F(+) cells from the episome. An E. coli mutant, whose RNA polymerase is resistant to rifampicin, does not show the curing. The growth of Hfr strains, which replicate the chromosome by the F-replication system, is inhibited by low doses of the antibiotic.Keywords
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