THE EFFECT OF RESERPINE ON THE PRESSOR RESPONSE TO INJECTION OF 2‐HALOGENOETHYLAMINE
Open Access
- 1 February 1961
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 16 (1), 77-81
- https://doi.org/10.1111/j.1476-5381.1961.tb00299.x
Abstract
Dibenamine-like compounds sometimes caused an increase in blood pressure when injected intravenously in mammals. This response varied with species, with the preparation, and with the structure of the compound. The response became smaller after repeated injections. In spinal atropinized rats injected with hexamethonium 5 mg/kg this pressor effect produced by injection of the adrenaline antagonist, compound AT3 [ethylfluoren-9-yl(2-iodoethyl)amine hydriodide], was reduced by prior treatment for five days with 1 mg/kg reserpine. Acute adrenalectomy also reduced this effect of the adrenaline antagonist; reserpine plus adrenalectomy abolished it. Subsequent injection of adrenaline and noradrenaline restored it.Keywords
This publication has 8 references indexed in Scilit:
- Structure and Activity in a Series of 2-HalogenoalkylaminesJournal of Medicinal Chemistry, 1960
- INCREASED URINARY EXCRETION OF ADRENALINE AND NORADRENALINE AFTER PHENOXYBENZAMINEBritish Journal of Pharmacology and Chemotherapy, 1959
- PLASMA ADRENALINE AND NORADRENALINE AFTER PHENOXYBENZAMINE ADMINISTRATION, AND DURING HAEMORRHAGIC HYPOTENSION, IN NORMAL AND ADRENALECTOMIZED DOGSBritish Journal of Pharmacology and Chemotherapy, 1959
- The release of chemical transmitter from the sympathetic nerves of the intestine of the catThe Journal of Physiology, 1958
- Effect of a Catechol Amine Blocking Agent (Dibenzyline) on Organ Content and Urine Excretion of Noradrenaline and AdrenalineActa Physiologica Scandinavica, 1958
- Noradrenaline in Artery Walls and its Dispersal by ReserpineBMJ, 1958
- The output of sympathetic transmitter from the spleen of the catThe Journal of Physiology, 1957
- THE ANTIHISTAMINE AND ANTIADRENALINE PROPERTIES OF A SERIES OF N‐NAPHTHYLMETHYL‐2‐HALO‐ETHYLAMINE DERIVATIVESBritish Journal of Pharmacology and Chemotherapy, 1953