Effects of cisapride on the secretion of pancreatic polypeptide in healthy volunteers.

Abstract

Plasma human pancreatic polypetide (hPP) responses to intravenous injections of a new gastric and intestinal motility promoting agent. R51 619 (cisapride), were studied in healthy volunteers. The mean fasting concentrations of plasma hPP (39 .+-. 5.4 pg/ml; mean .+-. S.E.) were elevated significantly to the peak values of 118 .+-. 25.1 pg/ml 30 min after the drug had been given in a dose of 4 mg over 5 min. However, plasma insulin (IRI), glucose and prolactin levels were not elevated. Atropine diminished the cisapride-induced hPP elevation, thereby suggesting that cisparide induced release of acetylcholine but had no antidopaminergic action.