Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease
Open Access
- 14 February 2017
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 317 (6), 626-634
- https://doi.org/10.1001/jama.2016.21042
Abstract
Obesity, typically defined on the basis of body mass index (BMI), is a leading cause of type 2 diabetes and coronary heart disease (CHD) in the population.1,2 However, for any given BMI, body fat distribution can vary substantially; some individuals store proportionally more fat around their visceral organs (abdominal adiposity) than on their thighs and hip.3 Waist-to-hip ratio (WHR) adjusted for BMI is a surrogate measure of abdominal adiposity and has been correlated with direct imaging assessments of abdominal fat.4,5Keywords
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