Complexes of Calcium and Magnesium with Oxytetracycline.
- 1 April 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (4), 797-801
- https://doi.org/10.3181/00379727-109-27339
Abstract
Calcium and magnesium binding by oxytetracycline (OTC), observed spectrophotometrically, occurs ina step-wise fashion. A variant of Job''s principle applies to these reactions. The log KCaOTC was found to be 3.0 and the log KCa2OTC 2.0. The log KMgOTC equaled 3.6, while log KMg2OTC was 2.4. Still higher metal to ligand complexes may exist, but the 1:1 and 2:1 OTC complexes are postulated to be the chief molecular species occurring in vivo.Keywords
This publication has 1 reference indexed in Scilit:
- The Solubility and Complexing Properties of Oxytetracycline and Tetracycline I. Interaction in Aqueous Solution**School of Pharmacy, University of Wisconsin, MadisonJournal of the American Pharmaceutical Association (Scientific ed.), 1957