Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (1), 63-66
- https://doi.org/10.1023/a:1012055401038
Abstract
Purpose. The aim of the work was to study iontophoretic transdermal administration of salmon calcitonin (sCt) in rabbits, with particular attention to drug reservoir composition. A dry sCt disc, to be dissolved on the application site, was used for preparing the reservoir for transdermal iontophoresis. As a reference drug reservoir, a pad wetted with drug solution was used. Methods. Experiments were done in rabbits depositing 100 IU of salmon calcitonin on skin and applying anodal iontophoresis. Serum calcium concentration was measured during iontophoresis, passive diffusion and after i.v. administration. Parameters such as pH value and reservoir type were examined. Results. Transdermal iontophoresis of sCt elicited a decrease in the serum calcium level, whereas, in the absence of electric current, no significant fall was measured. Using the reservoir prepared from drug solution, anodal iontophoresis at pH 4.2 was more effective than at pH 7.4, probably due to higher sCt net positive charge. Using the reservoir prepared from dry disc, similar kinetics and extent of drug effect were observed at both pH values. The reservoir prepared from solid drug deposit concentrated sCt next to the skin. Conclusions. Anodal iontophoresis for transdermal calcitonin administration shows therapeutical applicability. The type of reservoir is an important parameter affecting sCt transdermal iontophoresis.Keywords
This publication has 11 references indexed in Scilit:
- Utility of Pharmacodynamic Measures for Assessing the Oral Bioavailability of Peptides. 1. Administration of Recombinant Salmon Calcitonin in RatsJournal of Pharmaceutical Sciences, 1995
- Human Calcitonin Delivery in Rats by IontophoresisJournal of Pharmacy and Pharmacology, 1994
- Hypocalcemic effect of salmon calcitonin following single and repeated nasal and intravenous administration in young rabbitsCalcified Tissue International, 1994
- Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein DrugsPharmaceutical Research, 1993
- Effects of Proteolytic Enzyme Inhibitors as Absorption Enhancers on the Transdermal Iontophoretic Delivery of Calcitonin in RatsJournal of Pharmacy and Pharmacology, 1992
- Degradation of Synthetic Salmon Calcitonin in Aqueous SolutionPharmaceutical Research, 1992
- Influence of the Mobile Phase on Salmon Calcitonin Analysis by Reversed-Phase Liquid ChromatographyJournal of Chromatographic Science, 1991
- Percutaneous absorption of elcatonin and hypocalcemic effect in rat.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Total serum calcium concentrations in rabbits.1989
- Correlation of calcitonin structure with chromatographic retention in high-performance liquid chromatographyJournal of Chromatography A, 1988