Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids
- 1 March 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (3), 371-379
- https://doi.org/10.1021/jm00213a012
Abstract
A series of substituted chromone-2-carboxylic acids was synthesized and tested as antagonists of SRS-A [slow reacting substance of anaphylaxis] induced contractions of isolated guinea pig ileum. This work led to the discovery of sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxyl-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (FPL 55712) which is the 1st reported specific antagonist of SRS-A. Some structural requirements for biological activity within this series are discussed.This publication has 3 references indexed in Scilit:
- Antagonism of slow reacting substance in anaphylaxis (SRS-A) and other spasmogens on the guinea pig tracheal chain by hydratropic acids and their effects on anaphylaxisJournal of Medicinal Chemistry, 1975
- Antigen Induced Release of Histamine and SRS-A from Human Lung passively sensitized with Reaginic SerumNature, 1967
- The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shockThe Journal of Physiology, 1960