The Mechanism of Ketotifen-Induced Histamine Release from Human Peripheral Leucocytes
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 68 (2), 176-178
- https://doi.org/10.1159/000233090
Abstract
Ketotifen-induced histamine release from human leucocytes is independent of extracellular calcium and does not require metabolic energy. Furthermore, histamine release is accompanied by a loss of cellular cytoplasmic contents. This suggests that the mechanism of ketotifen-induced histamine release at high concentrations is non-specific and is similar to that of clemastine, a typical H1 antagonist.Keywords
This publication has 4 references indexed in Scilit:
- Evidence for the participation of calmodulin in stimulus–secretion coupling in the pancreatic β-cellBiochemical Journal, 1980
- Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazineInflammation Research, 1979
- Comparative Studies of Histamine Release and Potassium Efflux From Human Leukocytes.Experimental Biology and Medicine, 1966
- THE ANTI‐ANAPHYLACTIC AND HISTAMINE‐RELEASING PROPERTIES OF THE ANTIHISTAMINES. THEIR EFFECT ON THE MAST CELLSBritish Journal of Pharmacology and Chemotherapy, 1960