EXPERIMENTAL INDUCTION OF CHRONIC-BRONCHITIS IN DOGS - EFFECTS ON AIRWAY-OBSTRUCTION AND RESPONSIVENESS
- 1 January 1982
- journal article
- research article
- Published by Elsevier
- Vol. 126 (1), 75-79
- https://doi.org/10.1164/arrd.1982.126.1.75
Abstract
Chronic bronchitis was induced in 6 mongrel dogs by chronic exposure to SO2 gas; the degree of chronic airway obstruction and the effects on airway responsiveness to inhaled histamine, carbachol and prostaglandin F2.alpha. were examined. Five dogs developed chronic airway obstruction, as indicated by an increase in pulmonary resistance, and clinical mucous hypersecretion. In each of the animals in which chronic airway obstruction developed there was also a decrease in the airway responsiveness to inhaled mediators. Induction of chronic bronchitis in dogs results in hyporesponsiveness to inhaled mediators, a finding distinctly different from that in humans with naturally occurring disease.This publication has 12 references indexed in Scilit:
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