Mechanism localisation and control of restriction cleavage of phage T4 and λ chromosomes in vivo
- 1 April 1976
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 260 (5550), 406-410
- https://doi.org/10.1038/260406a0
Abstract
The primary action of restriction endonuclease, cleaving infecting DNA, has been demonstrated in vivo. This primary cleavage is followed rapidly by hydrolysis of the cleaved DNA at its newly exposed termini. Infecting viruses can inactivate cytoplasmic and membrane restriction endonucleases to prevent cleavage of unmodified DNA replicas.Keywords
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