INHIBITION OF TAMM‐HORSFALL GLYCOPROTEIN INDUCTION OF ALKALINE PHOSPHATASE IN CYSTIC FIBROSIS FIBROBLASTS BY MEDIUM CONDITIONED BY NORMAL CELLS
- 1 April 1979
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 57 (2), 225-230
- https://doi.org/10.1038/icb.1979.23
Abstract
It is confirmed that the level of alkaline phosphatase in fibroblasts derived from cystic fibrosis patients can be induced many-fold by growing the cells in the presence of Tamm-Horsfall glycoprotein. It is further shown that normal fibroblasts produce a "CF corrective factor" which markedly inhibits this phenomenon. These observations support a previous hypothesis on the nature of the metabolic defect in cystic fibrosis.Keywords
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