The CSF-protein patterns found by isoelectrie focusing and quantitative paper electrophoresis were studied in patients with extrapyramidal diseases. In four of five examined cases with Huntington’s chorea, very alkaline end fractions were found by isoelectric focusing in the CSF-γ-globulin region, the fractions being very pronounced in two cases and moderately pronounced in the other two. Double fractions in the same alkaline range were observed in one case with post-encephalitic chorea-athetosis. Two of three cases with parkinsonism had slightly pronounced and questionable alkaline end fractions, while such a fraction was not observed in a case of (treated) Wilson’s disease. Alkaline end fractions in the CSF-γ-globulin region with similar or the same isoelectric points have also been found in neurological diseases other than extrapyramidal disorders, especially in MS. It has to be shown if these alkaline end fractions consist of the same or different compounds, conceivable constituents being mentioned. The alkaline end fractions as well as fractions observed in other pH ranges by isoelectric focusing of CSF obviously call upon further investigations of CSF-proteins in extrapyramidal diseases.