Aberrant glycosylation associated with enzymes as cancer biomarkers
Open Access
- 3 June 2011
- journal article
- Published by Springer Nature in Clinical Proteomics
- Vol. 8 (1), 7
- https://doi.org/10.1186/1559-0275-8-7
Abstract
One of the new roles for enzymes in personalized medicine builds on a rational approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A hallmark of cancer, aberrant glycosylation is associated with differential expressions of enzymes such as glycosyltransferase and glycosidases. The aberrant expressions of the enzymes in turn cause cancer cells to produce glycoproteins with specific cancer-associated aberrations in glycan structures.Keywords
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