Inhibition of Adhesiveness and Aggregation of Dissociated Cells by Inhibitors of Protein and RNA Synthesis

Abstract

Mutual adhesiveness and aggregation of dissociated embryonic retina cells in suspension cultures are suppressed rapidly and reversibly by puromycin, an inhibitor of RNA-dependent protein synthesis; and at a slower rate, irreversibly, by actinomycin D, an inhibitor of RNA formation. The results imply that biosynthetic processes are involved in the mechanism of reattachment of these cells.