Aging in man. Linear increase of a novel T cell subset defined by antiganglioside monoclonal antibody 3G5.
Open Access
- 1 May 1987
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 165 (5), 1436-1441
- https://doi.org/10.1084/jem.165.5.1436
Abstract
A new human T cell subset defined by antineuronal ganglioside mAb 3G5 increases linearly with advancing age in man. The percentage of circulating 3G5+ T cells in 21 normal individuals, quantitated tby cytofluorograph analysis, increases linearly from age 7 (23-30%) to age 84 (58%) (r = 0.85, p < 0.001). The antigen on T cells has the biochemical properties of a ganglioside that migrate between GM1 and GM2 ganglioside markers on TLC. The 3G5 subset represents the first T cell subset that reflects aging in man.This publication has 14 references indexed in Scilit:
- Amiodarone therapy and autoimmune thyroid diseaseAmerican Journal Of Medicine, 1986
- Monoclonal Antibody Analysis of T-Lymphocyte Subsets in Young and Aged AdultsImmunological Communications, 1983
- Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.JCI Insight, 1983
- Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells.Proceedings of the National Academy of Sciences, 1982
- GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody.The Journal of Experimental Medicine, 1982
- An enzyme-linked immunosorbent assay (Elisa) for the detection of monoclonal antibodies to cell surface antigens on viable cellsJournal of Immunological Methods, 1981
- Monoclonal antibody to ganglioside gq discriminates between haemopoietic cells and infiltrating neuroblastoma tumour cells in bone marrowInternational Journal of Cancer, 1981
- The differentiation and function of human T lymphocytesCell, 1980
- A procedure for the quantitative isolation of brain gangliosidesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
- Biosynthesis and Function of GangliosidesScience, 1976