THE ROLE OF THE KININ SYSTEM IN VARIOUS INFLAMMATORY MODELS IN THE RAT

Abstract

The plasma of a peculiar strain of Brown Norway rats (MN/May Pfd f) is devoid of high MW kininogen and poor in kallikrein. This strain could be used to estimate the involvement of the kinin system in inflammatory processes. In these rats, the edema induced by kaolin, carrageenans, uric acid and urate crystals exhibited a small development, while the edemas induced by 48/80, dextran, zymosan, trypsin, nystatin, concanavalin A and heating were not reduced. The exudates withdrawn from Brown Norway rats contained no kinin and a low level of PGE2 [prostaglandin E2]. The involvement of the kinin system in these inflammatory models is discussed.