FERTILE EUNUCH SYNDROME VERSUS CLASSIC HYPOGONADOTROPHIC HYPOGONADISM
- 1 February 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 87 (2), 389-399
- https://doi.org/10.1530/acta.0.0870389
Abstract
The functioning of the hypothalmo-pituitary-target organs axis was assessed in 3 patients with fertile eunuch syndrome (FE) and 6 patients with classic hypogonadotrophic hypogonadism (HH) with or without hyposmia. Both groups of patients did not differ from each other with regard to basal serum prolactin levels, pituitary growth hormone and thyrotropin reserve and the thyroid or adrenal gland function. Both groups differed with respect to the hypothalamo-pituitary-gonadal function. The pituitary LH [luteinizing hormone] response to exogenous LH-RH [luteinzing hormone-releasing hormone] was (low)-normal in FE and blunted in HH. The basal FSH [follicle stimulating hormone] levels were normal in FE and undetectable in HH. The basal LH levels were normal in FE and 3 of 6 patients with HH and low in the remaining 3. The basal and HCG [human chorionic gonadotropin] stimulated plasma testosterone concentrations were significantly higher in FE than HH. FE may represent a less severe form of LH-RH deficiency, rather than a distinct disorder.This publication has 6 references indexed in Scilit:
- THE PITUITARY-THYROID AXIS IN KLINEFELTER's SYNDROMEActa Endocrinologica, 1977
- Clinical and Laboratory Heterogeneity in Idiopathic Hypogonadotropic HypogonadismJournal of Clinical Endocrinology & Metabolism, 1976
- Correlation Between Integrated LH and FSH Levels and the Response to Luteinizing Hormone Releasing Factor (LRF)Journal of Clinical Endocrinology & Metabolism, 1976
- The Response of Pituitary Gonadotropes to a Constant Infusion of Luteinizing Hormone-Releasing Hormone (LHRH) in Normal Prepubertal and Pubertal Children and in Children with Abnormalities of Sexual DevelopmentJournal of Clinical Endocrinology & Metabolism, 1976
- Studies on olfactory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration.JCI Insight, 1966
- A SYNDROME OF EUNUCHOIDISM WITH SPERMATOGENESIS, NORMAL URINARY FSH AND LOW OR NORMAL ICSH: (“FERTILE EUNUCHS”)*Journal of Clinical Endocrinology & Metabolism, 1953