Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2H‐1,4‐benzoxazine. Synthesis of a key intermediate of (S)‐(‐)‐ofloxacin (DR‐3355)
- 1 February 1991
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 28 (2), 329-331
- https://doi.org/10.1002/jhet.5570280222
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)Journal of Medicinal Chemistry, 1987
- Optical resolution of (R,S)-3-acetoxymethyl-7,8-difluoro-2,3-dihydro-4H-(1,4)benzoxazine.Agricultural and Biological Chemistry, 1987
- synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Synthesis and antibacterial activities of optically active ofloxacinAntimicrobial Agents and Chemotherapy, 1986
- Asymmetric synthesis using chirally modified borohydrides. Part 3. Enantioselective reduction of ketones and oxime ethers with reagents prepared from borane and chiral amino alcoholsJournal of the Chemical Society, Perkin Transactions 1, 1985
- ASYMMETRIC REDUCTION OF ALKYL ARYL KETONES WITH LITHIUM BOROHYDRIDE USING N-BENZOYLCYSTEINE AS CHIRAL LIGANDChemistry Letters, 1984
- Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Asymmetric reduction of cyclic imines with chiral sodium acyloxyborohydridesJournal of the Chemical Society, Perkin Transactions 1, 1983
- In vitro and in vivo activity of DL-8280, a new oxazine derivativeAntimicrobial Agents and Chemotherapy, 1982
- Asymmetric reduction of various ketones with the sodium salts of .ALPHA.-amino acid borane complexes.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979