5-HYDROXYTRYPTAMINE RECEPTORS - CONTRACTILE ACTIVITY AND MODE OF INHIBITION BY METHYSERGIDE IN MAMMALIAN INTRA-CRANICAL AND EXTRA-CRANIAL VESSELS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 243 (2), 245-254
Abstract
The contractile effect of 5-HT [serotonin] on intra- and extracranial arteries from rabbit, cat, dog and man and its interaction with methysergide was investigated. ED50 and EAm [the maximum contraction of the dose-response curve for 5-HT] values for 5-HT from both types of arteries differed. Intracranial arteries stimulated by 5-HT were more sensitive to methysergide than extracranial arteries. In intracranial vessels the methysergide antagonism is non-competitive while in extracranial it is competitive. These differences might suggest a heterogeneity of 5-HT receptors located within the cranial circulation.

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