Acute hemodynamic effects of cigarette smoking in man assessed by systolic time intervals and echocardiography.
- 1 October 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 60 (4), 752-760
- https://doi.org/10.1161/01.cir.60.4.752
Abstract
Sixteen healthy subjects, ages 18-35 yr, were studied in the supine position by systolic time intervals and echocardiography before and after smoking a high-nicotine cigarette (2.5 mg nicotine) and a tobacco cigarette of very low nicotine content (< 0.02 mg nicotine) to assess and compare the immediate effects upon left ventricular function. Smokers (n = 12) and nonsmokers (n = 4) behaved similarly. High- and low-nicotine cigarettes both caused significant increases in heart rate, systolic and diastolic blood pressure and the triple product (systolic blood pressure .times. left ventricular ejection .times. (LVET) .times. heart rate), prolonged LVETc and decreased the preejection period (PEP) and PEP/LVET. Smoking a nicotine reference cigarette increased the echocardiographically derived LV end-diastolic volume by 7.5%, augmented ejection fraction by 4%, while significantly enhancing mean normalized circumferential fiber shortening by 12.5% and mean normalized posterior wall velocity by 9%. Smoking a tobacco cigarette of ultra-low nicotine content resulted in comparable increases in ejection fraction and mean circumferential fiber shortening, albeit on the basis of a significant decrease in end-systolic volume without alteration in end-diastolic volume. In the supine position smoking a high-nicotine cigarette acutely increases venous return and augments the principal determinants of myocardial O2 consumption, heart rate, contractility, preload and afterload and cigarette smoke may contain inotropic and chronotropic substances other than nicotine.This publication has 15 references indexed in Scilit:
- Hemodynamic Effects of Smoking Cigarettes of High and Low Nicotine ContentChest, 1978
- Left ventricular function after cigarette smoking by chronic smokers: Comparison of normal subjects and patients with coronary artery diseaseThe American Journal of Cardiology, 1977
- Heart Rate and Carbon Monoxide Level After Smoking High-, Low-, and Non-Nicotine CigarettesAnnals of Internal Medicine, 1971
- Serum lipids, typing, fibrinolysis, and smoking.BMJ, 1970
- Non-Nicotinized Cigarettes and Angina PectorisAnnals of Internal Medicine, 1969
- Effects of Adrenergic Receptor Activation and Blockade on the Systolic Preejection Period, Heart Rate, and Arterial Pressure in ManJournal of Clinical Investigation, 1967
- Smoking in Relation to Atherosclerosis of the Coronary ArteriesNew England Journal of Medicine, 1965
- Cigarette Smoking and the in Vitro Thrombosis of Human BloodPublished by American Medical Association (AMA) ,1965
- ACTION OF NICOTINE ON THE HEARTAnnals of the New York Academy of Sciences, 1960