The influence of local infection on immunoglobulin formation in the human endocervix.
- 1 June 1972
- journal article
- Vol. 11 (2), 219-33
Abstract
The formation of immunoglobulins in the lamina propria of the endocervix was studied in relation to specific acute local infection. Plasma cells containing IgA, IgG and IgM were identified immunohistochemically by the direct fluorescent antibody method in specimens obtained by needle biopsy. Infection by Neisseria gonorrhoeae, Trichomonas vaginalis or Candida albicans was associated with an increse in the numbers of fluorescing plasma cells in all three classes, but predominantly IgA; plasma cells of the IgM class were more prominent in trichomoniasis than in the other two infections. Sexual contacts of patients with gonorrhoea, in whom the organism could not be demonstrated, showed an identical response to bacteriologically confirmed cases, but contacts of patients with non-specific urethritis were indistinguishable from normals.This publication has 16 references indexed in Scilit:
- The human female reproductive tract: Immunohistological localization of γA, γG, γM, secretory “piece,” and lactoferrinAmerican Journal of Obstetrics and Gynecology, 1970
- Diagnosis of vaginal discharge.Sexually Transmitted Infections, 1970
- Proteins of Cervical MucusNature, 1968
- IMMUNOGLOBULIN CONTENT OF INTESTINAL MUCOSAL PLASMA-CELLS IN ATAXIA TELANGIECTASIAThe Lancet, 1968
- THE DETECTION OF ANTIBODIES TO SPERMATOZOA AND TO BLOOD GROUP ANTIGENS IN CERVICAL MUCUSReproduction, 1967
- Antibody Synthesis in vitro by the Rabbit Vagina against Diphtheria ToxoidNature, 1967
- Serum proteins in cervical mucusAmerican Journal of Obstetrics and Gynecology, 1965
- Occurrence and Titer of Isohemagglutinins in Secretions of the Human Uterine Cervix.Experimental Biology and Medicine, 1961
- A PLEURAL-BIOPSY PUNCHThe Lancet, 1958
- Local antibody production in the mammary gland, spleen, uterus, vagina and appendix of the rabbitThe Journal of Pathology and Bacteriology, 1955