Analysis of Mixtures of Doxycycline and Oxytetracycline in Pharmaceutical Preparations by First Derivative Fluorimetry
- 1 May 1990
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 23 (5), 863-876
- https://doi.org/10.1080/00032719008052487
Abstract
The utility of first-derivative fluorimetry for the determination of doxycycline and oxytetracycline through the formation of their chelates with aluminium, is discussed. Mixtures of these compounds were determined by first-derivative fluorimetry with linear calibration graphs established between 0.2 and 1.4 μgml−1 for doxycycline and between 0.05 and 0.6 μgml−1 for oxytetracycline. The application of the method to the analysis of these compounds in pharmaceutical preparations is described and a statistical evaluation of the experimental results is reported.Keywords
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