DOSAGE EFFECTS AND INDIVIDUAL RESPONSIVITY TO METHYLPHENIDATE IN ATTENTION DEFICIT DISORDER
- 1 July 1988
- journal article
- research article
- Published by Wiley in Journal of Child Psychology and Psychiatry
- Vol. 29 (4), 453-475
- https://doi.org/10.1111/j.1469-7610.1988.tb00737.x
Abstract
Effects of three dosages of methylphenidate (0.15, 0.30 and 0.60 mg/kg) were assessed in 19 ADD-H children on a variety of cognitive, academic and behavioral measure in the laboratory and the classroom. A predominant linear pattern of improvement was found across almost all measures. A slight decrease between 0.3 and 0-.6 mg/kg on one cognitive task leaves open the possibility that higher dosages reduce stimulant effectiveness or cause decrements on some kinds of "high-level/high load" tasks. Response patterns of individual children varied considerably across measures. All children improved on at least several measures. Results were interpreted as evidence for stimulant activation of self-regulatory processes.Keywords
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