Differences in Histamine Content Found in Organs of Female and Male Guinea-Pigs

Abstract

Average histamine contents of normal lung, small intestine, skin of external ear, heart, liver, kidney and spleen were determined in 54 guinea-pig of both sexes, using two different strains. Average histamine contents of all organs except the spleen were higher in female guinea pigs. The difference of average histamine content in female lungs and small intestines compared to males is statistically significant. Average histamine levels of the spleen were significantly higher in male guinea pigs than in females. This difference seems to be a feature of the albino strain used.