Enzyme Induction

Abstract

Enzyme Induction and Drug MetabolismThe simultaneous administration of two or more drugs may result in interactions that increase or decrease the intended effects of one or both drugs.⁴⁴ These interactions are often the result of induced alterations in the metabolism of the drugs. A wide variety of unrelated chemical agents are also capable of enhancing the activity of drug-metabolizing enzymes, and this accelerated metabolism alters the duration and intensity of action of a variety of pharmacologic agents. The physiologic consequences of altered metabolism depend on the relative biologic activities of the parent compound and its metabolites.^{45 46 47} The enzymes involved . . .