IMMUNE RESPONSE ENGENDERED IN MICE BY MULTIPARITY

Abstract

Inbred females multiparous by males of an unrelated strain produced anti-male-strain hemagglutinins. Multiparity also abrogated the rejection reaction to allogeneic sajgpma grafts and conversely, height-ened the reaction to leukemia grafts when female and male differed at the H-2 locus. Where an interstrain mating was between mice of the same H-2 constitution, there was a diminished reaction to a male-strain leukemia graft. Attempts were unsuccessful to produce enhancement with sera from multiparous females. There was no correlation between the absence or presence of hemagglutinins in the multiparous females and their acceptance or rejection of allogeneic sarcoma grafts.