Correlation of Pituitary Ribonucleic Acid Levels and ACTH Production Following Adrenalectomy and Cortisone Administration.
- 1 February 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 106 (2), 420-422
- https://doi.org/10.3181/00379727-106-26357
Abstract
The concentration of RNA in pituitary tissue was determined following various periods of adrenalectomy and prolonged cortisone treatment. Elevations of pituitary RNA at 1/2 and 48 hours post-operatively correlate with increased tissue content of ACTH reported for the post-adrenalectomy periods. Reduction in the level of tissue RNA following cortisone administration likewise correlates with decreased amounts of ACTH in pituitaries reported after such treatment. The data, utilizing tissue RNA as an index of protein hormone synthetic activity, provide further information that indicate adrenal cortical steroids regulate synthesis of ACTH.Keywords
This publication has 8 references indexed in Scilit:
- Rat Anterior Pituitary Nucleic Acid Levels as Function of Age.Experimental Biology and Medicine, 1960
- The effects of hydrocortisone on the level of corticotrophin in the blood and pituitary glands of adrenalectomized and of stressed adrenalectomized ratsThe Journal of Physiology, 1960
- Nucleic Acid Levels of Rat Anterior Pituitary Glands Following Adrenalectomy.Experimental Biology and Medicine, 1959
- Effect of Hydrocortisone on Pituitary ACTH and Adrenal Weight in the Rat.Experimental Biology and Medicine, 1959
- Pituitary ACTH and Plasma Free Corticosteroids Following Bilateral Adrenalectomy in the Rat.Experimental Biology and Medicine, 1959
- THE EFFECT OF ADRENALECTOMY ON THE CIRCULATING LEVEL OF ADRENOCORTICOTROPHIC HORMONE IN THE RATJournal of Endocrinology, 1958
- EFFECT OF CORTICOTROPHIN ON THE CONTENT OF CORTICOTROPHIN IN THE PITUITARY GLANDS OF ADRENALECTOMIZED RATSActa Endocrinologica, 1957
- INCREASE IN THE FORMATION AND SECRETION OF ACTH FOLLOWING ADRENALECTOMY1Endocrinology, 1951