Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat
- 1 April 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (4), 392-394
- https://doi.org/10.1007/bf01959881
Abstract
The effect of acute ethanol ingestion (5 g/kg) by fasted rats, or chronic treatment in fed animals, revealed a significant decrease in the content of reduced glutathione of the liver and kidney. No changes were observed in reduced glutathione levels of the pancreas, intestines, stomach or spleen in the acute model. In this condition, the time course study of the decrease in reduced glutathione levels showed a progressive effect in the liver and a rapid and constant effect in the kidney.Keywords
This publication has 22 references indexed in Scilit:
- Effect of acute ethanol ingestion on lipoperoxidation and on the activity of the enzymes related to peroxide metabolism in rat liverFEBS Letters, 1980
- Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the ratFEBS Letters, 1980
- Increased biliary glutathione disulfide release in chronically ethanol‐treated ratsFEBS Letters, 1979
- Pathogenesis of alcohol-induced accumulation of protein in the liver.Journal of Clinical Investigation, 1977
- Role of Metabolic Activation in Chemical-Induced Tissue InjuryPublished by American Chemical Society (ACS) ,1977
- A Correlation between Glutathione Levels and Cellular Damage in Isolated HepatocytesEuropean Journal of Biochemistry, 1977
- The role of biotransformation in chemical-induced liver injury.Environmental Health Perspectives, 1976
- Diversion of ethanol metabolism by sulfhydryl amino acids. D-penicillamine-directed excretion of 2,5,5-trimethyl-D-thiazolidine-4-carboxylic acid in the urine of rats after ethanol administrationLife Sciences, 1975
- Protection against Acetaldehyde Toxicity in the rat byl-cysteine, thiamin andl-2-Methylthiazolidine-4-carboxylic acidInflammation Research, 1974
- EFFECTS OF CHRONIC INTAKE OF ETHANOL ON RATE OF ETHANOL METABOLISM: II. INFLUENCE OF SEX AND OF SCHEDULE OF ETHANOL ADMINISTRATIONCanadian Journal of Physiology and Pharmacology, 1967