Tuberculosis DNA Vaccines
- 1 January 2001
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Infectious Diseases
- Vol. 33 (4), 246-248
- https://doi.org/10.1080/003655401300077162
Abstract
DNA vaccines have been the subject of intense investigation for the past 10 y, during which time several tuberculosis (TB) DNA vaccines have been shown to confer protective immunity in animal models. So far, proof of principle for priming of immune responses by a naked DNA vaccine (malaria) has been demonstrated in humans, but potency remains a significant limitation. However, new DNA vaccine formulations and delivery systems are being developed with markedly improved potency in animal models. Therefore, there is a clear path to the human clinical testing of TB DNA vaccines.Keywords
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