The movement of molecules across lipid membranes: A molecular theory
- 1 December 1971
- journal article
- Published by Springer Nature in The Journal of Membrane Biology
- Vol. 4 (1), 193-208
- https://doi.org/10.1007/bf02431971
Abstract
The movement of molecules across membranes is discussed in terms of thermal fluctuations in the hydrocarbon chains of the membrane lipids. The thermal motion of the hydrocarbon chains results in the formation of conformational isomers, so-called kink-isomers of the hydrocarbon chains. “Kinks” may be pictured as mobile structural defects which represent small, mobile free volumes in the hydrocarbon phase of the membrane. The diffusion coefficient of kinks is calculated to be 10−5 cm2/sec; thus kinks diffusion is a fast process. Small molecules can enter into the free volumes of kinks and migrate across the membrane together with the kinks; thus kinks may be regarded as intrinsic carriers of lipid membranes. An expression is derived from this model for the flow of molecules through lipid membranes. The calculated value for the water permeability is compatible with measurements on lipid bilayers.Keywords
This publication has 21 references indexed in Scilit:
- X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawiiJournal of Molecular Biology, 1970
- Structure of aqueous mixtures of lecithin and cholesterolJournal of Molecular Biology, 1969
- Properties of liquid bilayer membranes separating two aqueous phases: Temperature dependence of water permeabilityJournal of Molecular Biology, 1969
- Permeability of Lipid Bilayer Membranes to Organic SolutesThe Journal of general physiology, 1968
- Water Permeability of Thin Lipid MembranesThe Journal of general physiology, 1967
- Eine neue Theorie zur Rotationsumwandlung der n-Paraffine (Kinkentheorie)Rheologica Acta, 1967
- The permeability to water of bimolecular lipid membranesJournal of Theoretical Biology, 1966
- Properties of lipid bilayer membranes separating two aqueous phases: Water permeabilityJournal of Molecular Biology, 1966
- Diffusion of water through hydrocarbon liquidsJournal of Polymer Science Part C: Polymer Symposia, 1965
- Monomolecular Layers of Synthetic PhosphatidesJournal of Pharmacy and Pharmacology, 1962