Characterization of an Integron Carrying a New Class Dβ-Lactamase (OXA-37) inAcinetobacter baumannii
- 1 December 2002
- journal article
- research article
- Published by Mary Ann Liebert Inc in Microbial Drug Resistance
- Vol. 8 (4), 261-265
- https://doi.org/10.1089/10766290260469516
Abstract
Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.Keywords
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