Dengue illness impacts daily human mobility patterns in Iquitos, Peru

Abstract

Human mobility plays a central role in shaping pathogen transmission by generating spatial and/or individual variability in potential pathogen-transmitting contacts. Recent research has shown that symptomatic infection can influence human mobility and pathogen transmission dynamics. Better understanding the complex relationship between symptom severity, infectiousness, and human mobility requires quantification of movement patterns throughout infectiousness. For dengue virus (DENV), human infectiousness peaks 0–2 days after symptom onset, making it paramount to understand human movement patterns from the beginning of illness. Through community-based febrile surveillance and RT-PCR assays, we identified a cohort of DENV+ residents of the city of Iquitos, Peru (n = 63). Using retrospective interviews, we measured the movements of these individuals when healthy and during each day of symptomatic illness. The most dramatic changes in mobility occurred during the first three days after symptom onset; individuals visited significantly fewer locations (Wilcoxon test, p = 0.017) and spent significantly more time at home (Wilcoxon test, p = 0.005), compared to when healthy. By 7–9 days after symptom onset, mobility measures had returned to healthy levels. Throughout an individual’s symptomatic period, the day of illness and their subjective sense of well-being were the most significant predictors for the number of locations and houses they visited. Our study is one of the first to collect and analyze human mobility data at a daily scale during symptomatic infection. Accounting for the observed changes in human mobility throughout illness will improve understanding of the impact of disease on DENV transmission dynamics and the interpretation of public health-based surveillance data. Dengue is the most important mosquito-borne viral disease of humans worldwide. Due to the limited mobility of the mosquitoes that transmit dengue virus, human mobility can be a key to both understanding an individual’s exposure to the virus and explaining the spread of dengue throughout a population. Accurate disease models should include human mobility; however, changes in human movement patterns due to the presence of symptoms need to be taken into account. We quantified the impact of symptom presence on human mobility throughout the infectious period by analyzing a dataset on the daily movements of dengue virus infected individuals. Accounting for these changing patterns of mobility will improve understanding of the complex relationship between symptom severity, human movement, and dengue virus transmission. Furthermore, dengue transmission models that incorporate symptom-driven mobility changes can be used to evaluate scenarios and strategies for disease prevention.